DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons

Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses gene expression. Here, we report that peripheral nerve injury increases expression of the DNA methyltransferase DNMT3a in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Zhao, Jian-Yuan, Liang, Lingli, Gu, Xiyao, Li, Zhisong, Wu, Shaogen, Sun, Linlin, Atianjoh, Fidelis E., Feng, Jian, Mo, Kai, Jia, Shushan, Lutz, Brianna Marie, Bekker, Alex, Nestler, Eric J., Tao, Yuan-Xiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344974/
https://ncbi.nlm.nih.gov/pubmed/28270689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14712
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge