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Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase
Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind impose severe topological constraints impedin...
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| Pubblicato in: | PLoS Genet |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5433769/ https://ncbi.nlm.nih.gov/pubmed/28463980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006754 |
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