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Targeting Mycobacterium tuberculosis Topoisomerase I by Small-Molecule Inhibitors

We describe inhibition of Mycobacterium tuberculosis topoisomerase I (MttopoI), an essential mycobacterial enzyme, by two related compounds, imipramine and norclomipramine, of which imipramine is clinically used as an antidepressant. These molecules showed growth inhibition of both Mycobacterium sme...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Godbole, Adwait Anand, Ahmed, Wareed, Bhat, Rajeshwari Subray, Bradley, Erin K., Ekins, Sean, Nagaraja, Valakunja
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325804/
https://ncbi.nlm.nih.gov/pubmed/25534741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04516-14
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