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Targeting Mycobacterium tuberculosis Topoisomerase I by Small-Molecule Inhibitors
We describe inhibition of Mycobacterium tuberculosis topoisomerase I (MttopoI), an essential mycobacterial enzyme, by two related compounds, imipramine and norclomipramine, of which imipramine is clinically used as an antidepressant. These molecules showed growth inhibition of both Mycobacterium sme...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Antimicrob Agents Chemother |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society for Microbiology
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4325804/ https://ncbi.nlm.nih.gov/pubmed/25534741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04516-14 |
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