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Genome-wide mapping of Topoisomerase I activity sites reveal its role in chromosome segregation

DNA Topoisomerase I (TopoI) in eubacteria is the principle DNA relaxase, belonging to Type 1A group. The enzyme from Mycobacterium smegmatis is essential for cell survival and distinct from other eubacteria in having several unusual characteristics. To understand genome-wide TopoI engagements in viv...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Rani, Phoolwanti, Nagaraja, Valakunja
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379724/
https://ncbi.nlm.nih.gov/pubmed/30566665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1271
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