Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant

The RNA-binding and -processing protein TAR DNA-binding protein 43 (TDP-43) is heavily linked to the underlying causes and pathology of neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In these diseases, TDP-43 is mislocalized, hyperphosphorylat...

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Publicado en:PLoS One
Autores principales: Wobst, Heike J., Delsing, Louise, Brandon, Nicholas J., Moss, Stephen J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433705/
https://ncbi.nlm.nih.gov/pubmed/28510586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177181
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