Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro

Mutations in the gene TARDBP, which encodes TAR DNA-binding protein 43 (TDP-43), are a rare cause of familial forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). While the majority of mutations are found in the C-terminal glycine-rich domain, an alanine to valine amino ac...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Wobst, Heike J., Wesolowski, Steven S., Chadchankar, Jayashree, Delsing, Louise, Jacobsen, Steven, Mukherjee, Jayanta, Deeb, Tarek Z., Dunlop, John, Brandon, Nicholas J., Moss, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323424/
https://ncbi.nlm.nih.gov/pubmed/28286471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00046
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