Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

USP14 is a cysteine protease deubiquitinase associated with the proteasome and plays important catalytic and allosteric roles in proteasomal degradation. USP14 inhibition has been considered a therapeutic strategy for accelerating degradation of aggregation-prone proteins in neurodegenerative diseas...

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Veröffentlicht in:PLoS One
Hauptverfasser: Chadchankar, Jayashree, Korboukh, Victoria, Conway, Leslie C., Wobst, Heike J., Walker, Chandler A., Doig, Peter, Jacobsen, Steve J., Brandon, Nicholas J., Moss, Stephen J., Wang, Qi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839854/
https://ncbi.nlm.nih.gov/pubmed/31703099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225145
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