Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14

Ubiquitin-specific protease 14 (USP14) is a major deubiquitinating enzyme and a key determinant of neuromuscular junction (NMJ) structure and function. We have previously reported dramatic ubiquitin depletion in the nervous systems of the USP14-deficient ataxia (ax(J)) mice and demonstrated that tra...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Vaden, Jada H., Watson, Jennifer A., Howard, Alan D., Chen, Ping-Chung, Wilson, Julie A., Wilson, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407586/
https://ncbi.nlm.nih.gov/pubmed/25954152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2015.00011
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