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Phosphazene-catalyzed desymmetrization of cyclohexadienones by dithiane addition

We report a desymmetrization of cyclohexadienones by intramolecular conjugate addition of a tethered dithiane nucleophile. Mild reaction conditions allow the formation of diversely functionalized fused bicyclic lactones. The products participate in facially selective additions from the convex surfac...

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Detalhes bibliográficos
Publicado no:Beilstein J Org Chem
Main Authors: Horwitz, Matthew A, Massolo, Elisabetta, Johnson, Jeffrey S
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433211/
https://ncbi.nlm.nih.gov/pubmed/28546832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.75
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