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Common sequence variants affect molecular function more than rare variants?

Any two unrelated individuals differ by about 10,000 single amino acid variants (SAVs). Do these impact molecular function? Experimental answers cannot answer comprehensively, while state-of-the-art prediction methods can. We predicted the functional impacts of SAVs within human and for variants bet...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Mahlich, Yannick, Reeb, Jonas, Hecht, Maximilian, Schelling, Maria, De Beer, Tjaart Andries Petrus, Bromberg, Yana, Rost, Burkhard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431670/
https://ncbi.nlm.nih.gov/pubmed/28487536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01054-2
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