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Predicted Molecular Effects of Sequence Variants Link to System Level of Disease

Developments in experimental and computational biology are advancing our understanding of how protein sequence variation impacts molecular protein function. However, the leap from the micro level of molecular function to the macro level of the whole organism, e.g. disease, remains barred. Here, we p...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: Reeb, Jonas, Hecht, Maximilian, Mahlich, Yannick, Bromberg, Yana, Rost, Burkhard
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990455/
https://ncbi.nlm.nih.gov/pubmed/27536940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005047
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