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Predicted Molecular Effects of Sequence Variants Link to System Level of Disease

Developments in experimental and computational biology are advancing our understanding of how protein sequence variation impacts molecular protein function. However, the leap from the micro level of molecular function to the macro level of the whole organism, e.g. disease, remains barred. Here, we p...

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Pubblicato in:PLoS Comput Biol
Autori principali: Reeb, Jonas, Hecht, Maximilian, Mahlich, Yannick, Bromberg, Yana, Rost, Burkhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990455/
https://ncbi.nlm.nih.gov/pubmed/27536940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005047
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