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Predicted Molecular Effects of Sequence Variants Link to System Level of Disease

Developments in experimental and computational biology are advancing our understanding of how protein sequence variation impacts molecular protein function. However, the leap from the micro level of molecular function to the macro level of the whole organism, e.g. disease, remains barred. Here, we p...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Comput Biol
Main Authors: Reeb, Jonas, Hecht, Maximilian, Mahlich, Yannick, Bromberg, Yana, Rost, Burkhard
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990455/
https://ncbi.nlm.nih.gov/pubmed/27536940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005047
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