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DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology

Here we demonstrate localization of the isoform3 of DNA Methyltransferase1 (DNMT1) enzyme to mitochondria, instead of isoform1 as reported earlier. The fused DNMT1-isoform1, reported earlier to localize in mitochondria, surprisingly showed its exclusive presence inside the nucleus after its ectopic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Saini, Sunil Kumar, Mangalhara, Kailash Chandra, Prakasam, Gopinath, Bamezai, R. N. K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431478/
https://ncbi.nlm.nih.gov/pubmed/28484249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01743-y
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