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Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase
DNA methyltransferase 1 (Dnmt1) has a central role in copying the pattern of DNA methylation after replication which is one manifestation of epigenetic inheritance. With oligonculeotide substrates we show that mouse Dnmt1 has a 30- to 40-fold preference for hemimethylated DNA that is almost lost aft...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383621/ https://ncbi.nlm.nih.gov/pubmed/16500889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl002 |
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