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The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro
The conversion of globular proteins into amyloid fibrils is associated with a wide variety of human diseases. One example is the prion protein (PrP), which adopts an α-helical structure in the native state but its amyloid form is implicated in the pathogenesis of prion diseases. Previous evidence ha...
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| Publicat a: | Sci Rep |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5429628/ https://ncbi.nlm.nih.gov/pubmed/28373719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00710-x |
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