Demethylated HSATII DNA and HSATII RNA foci sequester PRC1 and MeCP2 into cancer-specific nuclear bodies

This study reveals that high-copy satellite II (HSATII) sequences in the human genome can bind and impact distribution of chromatin regulatory proteins and that this goes awry in cancer. In many cancers, master regulatory proteins form two-types of cancer-specific nuclear bodies, caused by locus-spe...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Hall, Lisa L., Byron, Meg, Carone, Dawn M., Whitfield, Troy, Pouliot, Gayle P., Fischer, Andrew, Jones, Peter, Lawrence, Jeanne B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429029/
https://ncbi.nlm.nih.gov/pubmed/28329686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.072
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