Demethylated HSATII DNA and HSATII RNA foci sequester PRC1 and MeCP2 into cancer-specific nuclear bodies

This study reveals that high-copy satellite II (HSATII) sequences in the human genome can bind and impact distribution of chromatin regulatory proteins and that this goes awry in cancer. In many cancers, master regulatory proteins form two-types of cancer-specific nuclear bodies, caused by locus-spe...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Hall, Lisa L., Byron, Meg, Carone, Dawn M., Whitfield, Troy, Pouliot, Gayle P., Fischer, Andrew, Jones, Peter, Lawrence, Jeanne B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429029/
https://ncbi.nlm.nih.gov/pubmed/28329686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.072
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados