MeCP2 Levels Regulate the 3D Structure of Heterochromatic Foci in Mouse Neurons

Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein critical for normal brain function, and both depletion and overexpression of MeCP2 lead to severe neurodevelopmental disease, Rett syndrome (RTT) and MECP2 multiplication disorder, respectively. However, the molecular mechanism by which abnor...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ito-Ishida, Aya, Baker, Steven A., Sillitoe, Roy V., Sun, Yaling, Zhou, Jian, Ono, Yukiteru, Iwakiri, Junichi, Yuzaki, Michisuke, Zoghbi, Huda Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643291/
https://ncbi.nlm.nih.gov/pubmed/33046553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1281-19.2020
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