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MeCP2 Levels Regulate the 3D Structure of Heterochromatic Foci in Mouse Neurons

Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein critical for normal brain function, and both depletion and overexpression of MeCP2 lead to severe neurodevelopmental disease, Rett syndrome (RTT) and MECP2 multiplication disorder, respectively. However, the molecular mechanism by which abnor...

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Dades bibliogràfiques
Publicat a:J Neurosci
Autors principals: Ito-Ishida, Aya, Baker, Steven A., Sillitoe, Roy V., Sun, Yaling, Zhou, Jian, Ono, Yukiteru, Iwakiri, Junichi, Yuzaki, Michisuke, Zoghbi, Huda Y.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643291/
https://ncbi.nlm.nih.gov/pubmed/33046553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1281-19.2020
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