MeCP2 Levels Regulate the 3D Structure of Heterochromatic Foci in Mouse Neurons

Methyl-CpG binding protein 2 (MeCP2) is a nuclear protein critical for normal brain function, and both depletion and overexpression of MeCP2 lead to severe neurodevelopmental disease, Rett syndrome (RTT) and MECP2 multiplication disorder, respectively. However, the molecular mechanism by which abnor...

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Vydáno v:J Neurosci
Hlavní autoři: Ito-Ishida, Aya, Baker, Steven A., Sillitoe, Roy V., Sun, Yaling, Zhou, Jian, Ono, Yukiteru, Iwakiri, Junichi, Yuzaki, Michisuke, Zoghbi, Huda Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2020
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643291/
https://ncbi.nlm.nih.gov/pubmed/33046553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1281-19.2020
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