A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N (6)-methyladenosine demethylase FTO

The AlkB family of nucleic acid demethylases are of intense biological and medical interest because of their roles in nucleic acid repair and epigenetic modification. However their functional and molecular mechanisms are unclear, hence, there is strong interest in developing selective inhibitors for...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Toh, Joel D. W., Sun, Lingyi, Lau, Lisa Z. M., Tan, Jackie, Low, Joanne J. A., Tang, Colin W. Q., Cheong, Eleanor J. Y., Tan, Melissa J. H., Chen, Yun, Hong, Wanjin, Gao, Yong-Gui, Woon, Esther C. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424463/
https://ncbi.nlm.nih.gov/pubmed/28553460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc02554g
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