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A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N(6)-methyladenosine demethylase activity in cells

N (6)-Methyladenosine (m(6)A) is one of the most abundant epigenetic modifications on mRNA. It is dynamically regulated by the m(6)A demethylases FTO and ALKBH5, which are currently attracting intense medical interest because of their strong association with several human diseases. Despite their cli...

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Détails bibliographiques
Publié dans:Chem Sci
Auteurs principaux: Cheong, Adeline, Low, Joanne J. A., Lim, Andrea, Yen, Paul M., Woon, Esther C. Y.
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149071/
https://ncbi.nlm.nih.gov/pubmed/30288236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc02163e
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