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A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N(6)-methyladenosine demethylase activity in cells
N (6)-Methyladenosine (m(6)A) is one of the most abundant epigenetic modifications on mRNA. It is dynamically regulated by the m(6)A demethylases FTO and ALKBH5, which are currently attracting intense medical interest because of their strong association with several human diseases. Despite their cli...
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| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6149071/ https://ncbi.nlm.nih.gov/pubmed/30288236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc02163e |
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