Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery

Adjuvant properties of bacterial cell wall components like MPLA (monophosphoryl lipid A) are well described and have gained FDA approval for use in vaccines such as Cervarix. MPLA is the product of chemically modified lipooligosaccharide (LOS), altered to diminish toxic proinflammatory effects while...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Gregg, Kelsey A., Harberts, Erin, Gardner, Francesca M., Pelletier, Mark R., Cayatte, Corinne, Yu, Li, McCarthy, Michael P., Marshall, Jason D., Ernst, Robert K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424205/
https://ncbi.nlm.nih.gov/pubmed/28487429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00492-17
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