Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome

An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus. This high-resolution structural information demonstrated that a single amino acid deletion in riboso...

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Veröffentlicht in:mBio
Hauptverfasser: Belousoff, Matthew J., Eyal, Zohar, Radjainia, Mazdak, Ahmed, Tofayel, Bamert, Rebecca S., Matzov, Donna, Bashan, Anat, Zimmerman, Ella, Mishra, Satabdi, Cameron, David, Elmlund, Hans, Peleg, Anton Y., Bhushan, Shashi, Lithgow, Trevor, Yonath, Ada
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Observation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424203/
https://ncbi.nlm.nih.gov/pubmed/28487427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00395-17
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