Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding

Two structurally unique ribosomal antibiotics belonging to the orthosomycin family, avilamycin and evernimicin, possess activity against Enterococci, Staphylococci, and Streptococci, and other Gram-positive bacteria. Here, we describe the high-resolution crystal structures of the eubacterial large r...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Krupkin, Miri, Wekselman, Itai, Matzov, Donna, Eyal, Zohar, Diskin Posner, Yael, Rozenberg, Haim, Zimmerman, Ella, Bashan, Anat, Yonath, Ada
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098648/
https://ncbi.nlm.nih.gov/pubmed/27791159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614297113
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