Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome

An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus. This high-resolution structural information demonstrated that a single amino acid deletion in riboso...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Belousoff, Matthew J., Eyal, Zohar, Radjainia, Mazdak, Ahmed, Tofayel, Bamert, Rebecca S., Matzov, Donna, Bashan, Anat, Zimmerman, Ella, Mishra, Satabdi, Cameron, David, Elmlund, Hans, Peleg, Anton Y., Bhushan, Shashi, Lithgow, Trevor, Yonath, Ada
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Observation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424203/
https://ncbi.nlm.nih.gov/pubmed/28487427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00395-17
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