A ribonucleotide reductase inhibitor with deoxyribonucleoside‐reversible cytotoxicity

Ribonucleotide Reductase (RNR) is the sole enzyme that catalyzes the reduction of ribonucleotides into deoxyribonucleotides. Even though RNR is a recognized target for antiproliferative molecules, and the main target of the approved drug hydroxyurea, few new leads targeted to this enzyme have been d...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Oncol
Main Authors: Crona, Mikael, Codó, Paula, Jonna, Venkateswara Rao, Hofer, Anders, Fernandes, Aristi P., Tholander, Fredrik
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423217/
https://ncbi.nlm.nih.gov/pubmed/27511871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.07.008
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