A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover

Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to the corresponding deoxyribonucleotides, used in DNA synthesis and repair. Two different mechanisms help deliver the required electrons to the RNR active site. Formate can be used as reductant directly in the active site, o...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Loderer, Christoph, Jonna, Venkateswara Rao, Crona, Mikael, Rozman Grinberg, Inna, Sahlin, Margareta, Hofer, Anders, Lundin, Daniel, Sjöberg, Britt-Marie
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704485/
https://ncbi.nlm.nih.gov/pubmed/28972190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806331
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