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Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5794259/ https://ncbi.nlm.nih.gov/pubmed/29388911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31529 |
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