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Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic...
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| Publicado en: | eLife |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5794259/ https://ncbi.nlm.nih.gov/pubmed/29388911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31529 |
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