Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic...

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Publicado en:eLife
Autores principales: Rozman Grinberg, Inna, Lundin, Daniel, Hasan, Mahmudul, Crona, Mikael, Jonna, Venkateswara Rao, Loderer, Christoph, Sahlin, Margareta, Markova, Natalia, Borovok, Ilya, Berggren, Gustav, Hofer, Anders, Logan, Derek T, Sjöberg, Britt-Marie
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794259/
https://ncbi.nlm.nih.gov/pubmed/29388911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31529
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