Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations

The identification of mutations that are present at low frequencies in clinical samples is an essential component of precision medicine. The development of molecular barcoding for next-generation sequencing has greatly enhanced the sensitivity of detecting such mutations by massively parallel sequen...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mattox, Austin K., Wang, Yuxuan, Springer, Simeon, Cohen, Joshua D., Yegnasubramanian, Srinivasan, Nelson, William G., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422780/
https://ncbi.nlm.nih.gov/pubmed/28416672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701382114
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