Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations

The identification of mutations that are present at low frequencies in clinical samples is an essential component of precision medicine. The development of molecular barcoding for next-generation sequencing has greatly enhanced the sensitivity of detecting such mutations by massively parallel sequen...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mattox, Austin K., Wang, Yuxuan, Springer, Simeon, Cohen, Joshua D., Yegnasubramanian, Srinivasan, Nelson, William G., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422780/
https://ncbi.nlm.nih.gov/pubmed/28416672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701382114
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