The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can be increased and that the duration with which cohesin embraces DNA...

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發表在:Cell
Main Authors: Haarhuis, Judith H.I., van der Weide, Robin H., Blomen, Vincent A., Yáñez-Cuna, J. Omar, Amendola, Mario, van Ruiten, Marjon S., Krijger, Peter H.L., Teunissen, Hans, Medema, René H., van Steensel, Bas, Brummelkamp, Thijn R., de Wit, Elzo, Rowland, Benjamin D.
格式: Artigo
語言:Inglês
出版: Cell Press 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422210/
https://ncbi.nlm.nih.gov/pubmed/28475897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.04.013
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