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Paramagnetic relaxation enhancement for protein-observed (19)F NMR as an enabling approach for efficient fragment screening
Protein-observed (19)F (PrOF) NMR is an emerging tool for ligand discovery. To optimize the efficiency of PrOF NMR experiments, paramagnetic relaxation enhancement through the addition of chelated Ni(II) was used to shorten longitudinal relaxation time without causing significant line broadening. Th...
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| Опубликовано в: : | RSC Adv |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5421645/ https://ncbi.nlm.nih.gov/pubmed/28496971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6RA21226C |
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