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Paramagnetic relaxation enhancement for protein-observed (19)F NMR as an enabling approach for efficient fragment screening
Protein-observed (19)F (PrOF) NMR is an emerging tool for ligand discovery. To optimize the efficiency of PrOF NMR experiments, paramagnetic relaxation enhancement through the addition of chelated Ni(II) was used to shorten longitudinal relaxation time without causing significant line broadening. Th...
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| 出版年: | RSC Adv |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5421645/ https://ncbi.nlm.nih.gov/pubmed/28496971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6RA21226C |
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