Tumor-infiltrating Merkel cell polyomavirus-specific T cells are diverse and associated with improved patient survival

Tumor-infiltrating CD8(+) T cells are associated with improved survival of patients with Merkel cell carcinoma (MCC), an aggressive skin cancer causally linked to Merkel cell polyomavirus (MCPyV). However, CD8(+) T-cell infiltration is robust in only 4%–18% of MCC tumors. We characterized the T-cell...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Miller, Natalie J., Church, Candice D., Dong, Lichun, Crispin, David, Fitzgibbon, Matthew P., Lachance, Kristina, Jing, Lichen, Shinohara, Michi, Gavvovidis, Ioannis, Willimsky, Gerald, McIntosh, Martin, Blankenstein, Thomas, Koelle, David M., Nghiem, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421625/
https://ncbi.nlm.nih.gov/pubmed/28093446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-16-0210
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