Human CD4(+) T cells specific for Merkel cell polyomavirus localize to Merkel cell carcinomas and target a required oncogenic domain

Although CD4(+) T cells likely play key roles in antitumor immune responses, most immuno-oncology studies have been limited to CD8(+) T-cell responses due to multiple technical barriers and a lack of shared antigens across patients. Merkel cell carcinoma (MCC) is an aggressive skin cancer caused by...

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Udgivet i:Cancer Immunol Res
Main Authors: Longino, Natalie V., Yang, Junbao, Iyer, Jayasri G., Ibrani, Dafina, Chow, I-Ting, Laing, Kerry J., Campbell, Victoria L., Paulson, Kelly G., Kulikauskas, Rima M., Church, Candice D., James, Eddie A., Nghiem, Paul, Kwok, William W., Koelle, David M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774871/
https://ncbi.nlm.nih.gov/pubmed/31405946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0103
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