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Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling
The broad substrate tolerance of tubulin tyrosine ligase is the basic rationale behind its wide applicability for chemoenzymatic protein functionalization. In this context, we report that the wild-type enzyme enables ligation of various unnatural amino acids that are substantially bigger than and st...
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| Опубликовано в: : | Chem Sci |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Royal Society of Chemistry
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5418632/ https://ncbi.nlm.nih.gov/pubmed/28507719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00574a |
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