Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling

The broad substrate tolerance of tubulin tyrosine ligase is the basic rationale behind its wide applicability for chemoenzymatic protein functionalization. In this context, we report that the wild-type enzyme enables ligation of various unnatural amino acids that are substantially bigger than and st...

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Publicat a:Chem Sci
Autors principals: Schumacher, Dominik, Lemke, Oliver, Helma, Jonas, Gerszonowicz, Lena, Waller, Verena, Stoschek, Tina, Durkin, Patrick M., Budisa, Nediljko, Leonhardt, Heinrich, Keller, Bettina G., Hackenberger, Christian P. R.
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2017
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418632/
https://ncbi.nlm.nih.gov/pubmed/28507719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00574a
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