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Effects of macromolecular crowding agents on protein folding in vitro and in silico

Proteins fold and function inside cells which are environments very different from that of dilute buffer solutions most often used in traditional experiments. The crowded milieu results in excluded-volume effects, increased bulk viscosity and amplified chances for inter-molecular interactions. These...

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Détails bibliographiques
Publié dans:Biophys Rev
Auteurs principaux: Christiansen, Alexander, Wang, Qian, Cheung, Margaret S., Wittung-Stafshede, Pernilla
Format: Artigo
Langue:Inglês
Publié: Springer-Verlag 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418436/
https://ncbi.nlm.nih.gov/pubmed/28510156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12551-013-0108-0
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