The Nuclear Orphan Receptor Nur77 Is a Lipotoxicity Sensor Regulating Glucose-Induced Insulin Secretion in Pancreatic β-Cells

The NR4A orphan nuclear receptors Nur77, Nurr1, and Nor1 exert multiple cellular and metabolic functions. These transcriptional regulators are activated in response to extracellular stresses, including lipotoxic fatty acids (FA) and proinflammatory cytokines. The contribution of NR4As to β-cell path...

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Bibliographic Details
Published in:Mol Endocrinol
Main Authors: Briand, Olivier, Helleboid-Chapman, Audrey, Ploton, Maheul, Hennuyer, Nathalie, Carpentier, Rodolphe, Pattou, François, Vandewalle, Brigitte, Moerman, Ericka, Gmyr, Valery, Kerr-Conte, Julie, Eeckhoute, Jérôme, Staels, Bart, Lefebvre, Philippe
Format: Artigo
Language:Inglês
Published: Endocrine Society 2012
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417130/
https://ncbi.nlm.nih.gov/pubmed/22301783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1317
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