The Nuclear Orphan Receptor Nur77 Is a Lipotoxicity Sensor Regulating Glucose-Induced Insulin Secretion in Pancreatic β-Cells

The NR4A orphan nuclear receptors Nur77, Nurr1, and Nor1 exert multiple cellular and metabolic functions. These transcriptional regulators are activated in response to extracellular stresses, including lipotoxic fatty acids (FA) and proinflammatory cytokines. The contribution of NR4As to β-cell path...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Briand, Olivier, Helleboid-Chapman, Audrey, Ploton, Maheul, Hennuyer, Nathalie, Carpentier, Rodolphe, Pattou, François, Vandewalle, Brigitte, Moerman, Ericka, Gmyr, Valery, Kerr-Conte, Julie, Eeckhoute, Jérôme, Staels, Bart, Lefebvre, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417130/
https://ncbi.nlm.nih.gov/pubmed/22301783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1317
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