Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats

Trinucleotide repeats are a source of genome instability, causing replication fork stalling, chromosome fragility, and impaired repair. Specialized helicases play an important role in unwinding DNA structures to maintain genome stability. The Srs2 helicase unwinds DNA hairpins, facilitates replicati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Nguyen, Jennifer H.G., Viterbo, David, Anand, Ranjith P., Verra, Lauren, Sloan, Laura, Richard, Guy-Franck, Freudenreich, Catherine H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Genome Integrity, Repair and Replication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416882/
https://ncbi.nlm.nih.gov/pubmed/28175398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx088
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