Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats

Trinucleotide repeats are a source of genome instability, causing replication fork stalling, chromosome fragility, and impaired repair. Specialized helicases play an important role in unwinding DNA structures to maintain genome stability. The Srs2 helicase unwinds DNA hairpins, facilitates replicati...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Nguyen, Jennifer H.G., Viterbo, David, Anand, Ranjith P., Verra, Lauren, Sloan, Laura, Richard, Guy-Franck, Freudenreich, Catherine H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416882/
https://ncbi.nlm.nih.gov/pubmed/28175398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx088
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