Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Structure
Päätekijät: Aryal, Prafulla, Jarerattanachat, Viwan, Clausen, Michael V., Schewe, Marcus, McClenaghan, Conor, Argent, Liam, Conrad, Linus J., Dong, Yin Y., Pike, Ashley C.W., Carpenter, Elisabeth P., Baukrowitz, Thomas, Sansom, Mark S.P., Tucker, Stephen J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cell Press 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415359/
https://ncbi.nlm.nih.gov/pubmed/28392258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.03.006
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia