Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation

BACKGROUND. Melanoma is a heterogeneous malignancy. We set out to identify the molecular underpinnings of high-risk melanomas, those that are likely to progress rapidly, metastasize, and result in poor outcomes. METHODS. We examined transcriptome changes from benign states to early-, intermediate-,...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Badal, Brateil, Solovyov, Alexander, Di Cecilia, Serena, Chan, Joseph Minhow, Chang, Li-Wei, Iqbal, Ramiz, Aydin, Iraz T., Rajan, Geena S., Chen, Chen, Abbate, Franco, Arora, Kshitij S., Tanne, Antoine, Gruber, Stephen B., Johnson, Timothy M., Fullen, Douglas R., Raskin, Leon, Phelps, Robert, Bhardwaj, Nina, Bernstein, Emily, Ting, David T., Brunner, Georg, Schadt, Eric E., Greenbaum, Benjamin D., Celebi, Julide Tok
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414564/
https://ncbi.nlm.nih.gov/pubmed/28469092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92102
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