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Assessment of disulfide and hinge modifications in monoclonal antibodies

During the last years there was a substantial increase in the use of antibodies and related proteins as therapeutics. The emphasis of the pharmaceutical industry is on IgG1, IgG2, and IgG4 antibodies, which are therefore in the focus of this article. In order to ensure appropriate quality control of...

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Publicat a:Electrophoresis
Autors principals: Moritz, Bernd, Stracke, Jan Olaf
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413849/
https://ncbi.nlm.nih.gov/pubmed/27982442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elps.201600425
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