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Reduction-Alkylation Strategies for the Modification of Specific Monoclonal Antibody Disulfides

Site-specific conjugation of small molecules and enzymes to monoclonal antibodies has broad utility in the formation of conjugates for therapeutic, diagnostic, or structural applications. Precise control over the location of conjugation would yield highly homogenous materials that could have improve...

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Detalhes bibliográficos
Main Authors: Sun, Michael M.C., Beam, Kevin S., Cerveny, Charles G., Hamblett, Kevin J., Blackmore, Richard S., Torgov, Michael Y., Handley, Felicia G.M., Senter, Peter D., Alley, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2539111/
https://ncbi.nlm.nih.gov/pubmed/16173809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc050201y
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