Reduction in C-terminal amidated species of recombinant monoclonal antibodies by genetic modification of CHO cells

BACKGROUND: During development of recombinant monoclonal antibodies in Chinese hamster ovary (CHO) cells, C-terminal amidated species are observed. C-terminal amidation is catalysed by peptidylglycine α-amidating monooxygenase (PAM), an enzyme known to be expressed in CHO cells. The significant vari...

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Hlavní autoři: Škulj, Mihaela, Pezdirec, Dejan, Gaser, Dominik, Kreft, Marko, Zorec, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146454/
https://ncbi.nlm.nih.gov/pubmed/25123359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-14-76
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