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Reduction in C-terminal amidated species of recombinant monoclonal antibodies by genetic modification of CHO cells
BACKGROUND: During development of recombinant monoclonal antibodies in Chinese hamster ovary (CHO) cells, C-terminal amidated species are observed. C-terminal amidation is catalysed by peptidylglycine α-amidating monooxygenase (PAM), an enzyme known to be expressed in CHO cells. The significant vari...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4146454/ https://ncbi.nlm.nih.gov/pubmed/25123359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-14-76 |
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