Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects

Manufacturing-induced disulfide reduction has recently been reported for monoclonal human immunoglobulin gamma (IgG) antibodies, a widely used modality in the biopharmaceutical industry. This effect has been tied to components of the intracellular thioredoxin reduction system that are released upon...

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Detalhes bibliográficos
Main Authors: Hutterer, Katariina M., Hong, Robert W., Lull, Jonathon, Zhao, Xiaoyang, Wang, Tian, Pei, Rex, Le, M. Eleanor, Borisov, Oleg, Piper, Rob, Liu, Yaoqing Diana, Petty, Krista, Apostol, Izydor, Flynn, Gregory C.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906314/
https://ncbi.nlm.nih.gov/pubmed/23751615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24725
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